Coagulant factor Xa inhibits prostacyclin formation in human endothelial cells. Role of factor V.
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چکیده
منابع مشابه
Cleavage requirements for activation of factor V by factor Xa.
Coagulation factor V circulates in plasma as a single chain protein which expresses little procoagulant activity. After its activation by limited proteolysis by thrombin or factor Xa, factor Va functions as cofactor to factor Xa in the activation of prothrombin. Thrombin cleaves human factor V at Arg709, Arg1018 and Arg1545 and factor Va is formed by the heavy and light chains, which correspond...
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ژورنال
عنوان ژورنال: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
سال: 1985
ISSN: 0276-5047
DOI: 10.1161/01.atv.5.3.244